Screenshot

Downloading Large Files with Curl

Some users who have trouble downloading large reference panels due to virus scanning or other security considerations. Curl, which comes pre-installed on most unix-based operating systems can be can be used to directly download reference panels. To do so, copy and paste the following commands into a terminal window:

  1. Download the HapMap Variant reference panel: 
    curl --header 'Host: drive.usercontent.google.com' --header 'User-Agent: Mozilla/5.0 (X11; Linux x86_64) AppleWebKit/537.36 (KHTML, like Gecko) Chrome/129.0.0.0 Safari/537.36' --header 'Accept: text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7' --header 'Accept-Language: en-US,en;q=0.9' --header 'Cookie: HSID=AoF9m_6tVeb09qDxB; SSID=AD-DXipuaombsBh0h; APISID=q36TGuYIe-cEv-fE/AV2VZf2ieU1cq1Igl; SAPISID=xMDkAfz0wKEwv8TL/A0IzvH3245W_Ao0TJ; __Secure-1PAPISID=xMDkAfz0wKEwv8TL/A0IzvH3245W_Ao0TJ; __Secure-3PAPISID=xMDkAfz0wKEwv8TL/A0IzvH3245W_Ao0TJ; S=billing-ui-v3=a9O0G9E9aDMupi7g1hLo9JY8pXcOwjYg:billing-ui-v3-efe=a9O0G9E9aDMupi7g1hLo9JY8pXcOwjYg; __Secure-ENID=23.SE=FF3F14B6WvDGdNY5IVFcjj2qMFKbGWbbjhNqiqkLxFG2oHfHtt2tnXGCjAJnTCwVqcrWEEapt_NteVQfEW9i-qtpqxLaTLsFUk0JJh5qvD4b2UEOcGaSqyltxuGQkoHrttfymgP4TMrPCfTMNt2xAzDGhFWMQ7REnQx_SPlhgAz9eJ07dMOaz6lOzNS5qkrwlQYPIUXE3AHGzg_mPEBKVtSiswkg71k8r8nnQ8Kkhdr8QlPxKEDjkocnV-hzhxClKWvI8aszkoNVLnopDdl7d-FRVb2FB3y_zLdcuty_lovUluU2qnxK67ZqLs_haSiIwupaDyLlLFvOlNgHQgUa3jQIal3QG3JAGhMOUPdNFga49A; SID=g.a000pwh4bxY6L7SRGa2NgTvkbkHqowyFc-VmrsLTBb4Bn-glvwPWmUosf97LDrHCniV3rhU9jwACgYKATASARUSFQHGX2Mi1AX2gxbq-i-IgVZBvuXcixoVAUF8yKqjQkGjJlIxv0GRnpcmeuWR0076; __Secure-1PSID=g.a000pwh4bxY6L7SRGa2NgTvkbkHqowyFc-VmrsLTBb4Bn-glvwPWZW2LCQ1nPyRoEV8PrMbcUAACgYKAU4SARUSFQHGX2MiDyMcSgv-3DYYi74i6Duf4xoVAUF8yKp2kt2FakB5-fVOlflvj18v0076; __Secure-3PSID=g.a000pwh4bxY6L7SRGa2NgTvkbkHqowyFc-VmrsLTBb4Bn-glvwPW_Mr9JgT-NhNItkIbcdUF8wACgYKAdcSARUSFQHGX2MiiAFSVmBNls1NPOhNHjBLrxoVAUF8yKr_B6OKBO5LEiZlqI8FhMdS0076; OSID=g.a000pgh4b5JZdIOotyBDt4f48llvybqkk49ek_LxWzjMUSyoX4tybN3JFc2uTfjP5DXeFzS7AQACgYKAbUSARUSFQHGX2MiiUeSGldKclTsgKYQ8hrK8BoVAUF8yKpfq61K8N8xSZ8IiJ-Fqsji0076; __Secure-OSID=g.a000pgh4b5JZdIOotyBDt4f48llvybqkk49ek_LxWzjMUSyoX4tyK6Ij1mUddYQFg7JOy35pXAACgYKAe4SARUSFQHGX2Mine7zuzmciEmpjJ00r_eMpRoVAUF8yKowhBBZbgC77Arqx6wbfA870076; AEC=AZ6Zc-XlHyhyvDszKJ2zEd5oHwFuRMhi50rJ5j554OKU8f2gP8qs5Sy2zw; NID=519=YRAuI47MT-mQo1GMo8ySboib3Ggz35QGzn9I5GE9fCuRRDtAA60P8wEyp2T96V1H7EDPsq9CLXWrgr_uh9SujYeMolN6bjWX6mZDJhmmNQCNeoTZEj2_nqFXa3lKIAJtjT2zDLpkBy7fNA7Plckn9-n1_2TUJI8kwcgy2ZTvk5EFc2Mqnk4LxkzefChabQCkgdKtCr7QQeamGGKs5AdKOQOz0emHwJopegGUUJFbCMbMkjGuO52Svezn8Rj7gINZdsRzSxu75rGKK3O73lyOO2PEyvzu7Tsj3Zf9UOkzOqDwfXJ-Xyl-zO_ZSPQP3E9bOeWOZPn4L8l2JXGviLU1st-hsbLuvjnUF1luZXTKwBKN3JennoNQl0HBzZSJ5Ls5n0VNAemgMA; __Secure-1PSIDTS=sidts-CjIBQT4rXwZpOKdQy5TXWSxL4jIPtSRaJFs9sFIhmbtDRQikUZ53Jwj7fcX6lJ_B2XZAwxAA; __Secure-3PSIDTS=sidts-CjIBQT4rXwZpOKdQy5TXWSxL4jIPtSRaJFs9sFIhmbtDRQikUZ53Jwj7fcX6lJ_B2XZAwxAA; SIDCC=AKEyXzXdf_K-T2xDIIC8B3u8HwTTj1bgS7NWtuOoIbHBvKIAySJebLoDEKCFyBaeot0gCtzrdRfb; __Secure-1PSIDCC=AKEyXzUQZ3S0ZpOBXzAmVcxIzaO8flwb1r42dJRNKsb4t1-Lq-1fe9RjH8BnXDB22rBUgs4NXgM; __Secure-3PSIDCC=AKEyXzWjkZxmjK5PRQxgU3THuSE10-vsuQYsuIbbQU8j0Y7clgK3U0I7ChwHlpTJWTE3FyBXW54' --header 'Connection: keep-alive' 'https://drive.usercontent.google.com/download?id=1D0ZtPrvkvznKfHjlwo6BkYIvWFIRF_9g&export=download&authuser=0&confirm=t&uuid=127669d2-7954-4e1b-9d0c-d8d69b9418d8&at=AENtkXb6-Rr6VvS4cAMuVrt0rLg1%3A1732553440826' -L -o 'HapMap_Variants.tar.gz'
  2. Download the 1000 Genomes Variants (MAF > 5%): 
    curl --header 'Host: drive.usercontent.google.com' --header 'User-Agent: Mozilla/5.0 (X11; Linux x86_64) AppleWebKit/537.36 (KHTML, like Gecko) Chrome/129.0.0.0 Safari/537.36' --header 'Accept: text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7' --header 'Accept-Language: en-US,en;q=0.9' --header 'Cookie: HSID=AoF9m_6tVeb09qDxB; SSID=AD-DXipuaombsBh0h; APISID=q36TGuYIe-cEv-fE/AV2VZf2ieU1cq1Igl; SAPISID=xMDkAfz0wKEwv8TL/A0IzvH3245W_Ao0TJ; __Secure-1PAPISID=xMDkAfz0wKEwv8TL/A0IzvH3245W_Ao0TJ; __Secure-3PAPISID=xMDkAfz0wKEwv8TL/A0IzvH3245W_Ao0TJ; S=billing-ui-v3=a9O0G9E9aDMupi7g1hLo9JY8pXcOwjYg:billing-ui-v3-efe=a9O0G9E9aDMupi7g1hLo9JY8pXcOwjYg; __Secure-ENID=23.SE=FF3F14B6WvDGdNY5IVFcjj2qMFKbGWbbjhNqiqkLxFG2oHfHtt2tnXGCjAJnTCwVqcrWEEapt_NteVQfEW9i-qtpqxLaTLsFUk0JJh5qvD4b2UEOcGaSqyltxuGQkoHrttfymgP4TMrPCfTMNt2xAzDGhFWMQ7REnQx_SPlhgAz9eJ07dMOaz6lOzNS5qkrwlQYPIUXE3AHGzg_mPEBKVtSiswkg71k8r8nnQ8Kkhdr8QlPxKEDjkocnV-hzhxClKWvI8aszkoNVLnopDdl7d-FRVb2FB3y_zLdcuty_lovUluU2qnxK67ZqLs_haSiIwupaDyLlLFvOlNgHQgUa3jQIal3QG3JAGhMOUPdNFga49A; SID=g.a000pwh4bxY6L7SRGa2NgTvkbkHqowyFc-VmrsLTBb4Bn-glvwPWmUosf97LDrHCniV3rhU9jwACgYKATASARUSFQHGX2Mi1AX2gxbq-i-IgVZBvuXcixoVAUF8yKqjQkGjJlIxv0GRnpcmeuWR0076; __Secure-1PSID=g.a000pwh4bxY6L7SRGa2NgTvkbkHqowyFc-VmrsLTBb4Bn-glvwPWZW2LCQ1nPyRoEV8PrMbcUAACgYKAU4SARUSFQHGX2MiDyMcSgv-3DYYi74i6Duf4xoVAUF8yKp2kt2FakB5-fVOlflvj18v0076; __Secure-3PSID=g.a000pwh4bxY6L7SRGa2NgTvkbkHqowyFc-VmrsLTBb4Bn-glvwPW_Mr9JgT-NhNItkIbcdUF8wACgYKAdcSARUSFQHGX2MiiAFSVmBNls1NPOhNHjBLrxoVAUF8yKr_B6OKBO5LEiZlqI8FhMdS0076; OSID=g.a000pgh4b5JZdIOotyBDt4f48llvybqkk49ek_LxWzjMUSyoX4tybN3JFc2uTfjP5DXeFzS7AQACgYKAbUSARUSFQHGX2MiiUeSGldKclTsgKYQ8hrK8BoVAUF8yKpfq61K8N8xSZ8IiJ-Fqsji0076; __Secure-OSID=g.a000pgh4b5JZdIOotyBDt4f48llvybqkk49ek_LxWzjMUSyoX4tyK6Ij1mUddYQFg7JOy35pXAACgYKAe4SARUSFQHGX2Mine7zuzmciEmpjJ00r_eMpRoVAUF8yKowhBBZbgC77Arqx6wbfA870076; AEC=AZ6Zc-XlHyhyvDszKJ2zEd5oHwFuRMhi50rJ5j554OKU8f2gP8qs5Sy2zw; NID=519=YRAuI47MT-mQo1GMo8ySboib3Ggz35QGzn9I5GE9fCuRRDtAA60P8wEyp2T96V1H7EDPsq9CLXWrgr_uh9SujYeMolN6bjWX6mZDJhmmNQCNeoTZEj2_nqFXa3lKIAJtjT2zDLpkBy7fNA7Plckn9-n1_2TUJI8kwcgy2ZTvk5EFc2Mqnk4LxkzefChabQCkgdKtCr7QQeamGGKs5AdKOQOz0emHwJopegGUUJFbCMbMkjGuO52Svezn8Rj7gINZdsRzSxu75rGKK3O73lyOO2PEyvzu7Tsj3Zf9UOkzOqDwfXJ-Xyl-zO_ZSPQP3E9bOeWOZPn4L8l2JXGviLU1st-hsbLuvjnUF1luZXTKwBKN3JennoNQl0HBzZSJ5Ls5n0VNAemgMA; __Secure-1PSIDTS=sidts-CjIBQT4rX9aHHfFL0QD5RBy5a2HOFYfa88q3NGcsBZD6Y95-jmz5wSzppyslHwxry8VJxRAA; __Secure-3PSIDTS=sidts-CjIBQT4rX9aHHfFL0QD5RBy5a2HOFYfa88q3NGcsBZD6Y95-jmz5wSzppyslHwxry8VJxRAA; SIDCC=AKEyXzW546Ti6p14-6zmjsZWF-Gqszb1Te985LhLWQ97A0jLjDMC-Q3ToFL9AB-a6FXdJuBLhc1z; __Secure-1PSIDCC=AKEyXzV_wMM7inJCoyXTtigBAmUBabnLS-7AJv0bS5x11saCZaGIoOmvG-jn-L7xpHOt-EeWBtI; __Secure-3PSIDCC=AKEyXzWywTxQSXpMjGbGJ90jmmWIIfVGjv1_aZEJWPgYUoE5NfN9G5Bfiik01IgMyY6n7nrPfXk' --header 'Connection: keep-alive' 'https://drive.usercontent.google.com/download?id=1c3BamSz1JpXr0QQIfyI_1nUfe0SRNXKa&export=download&authuser=0&confirm=t&uuid=4643f2b5-84eb-4895-aff2-dcecc725b06d&at=AENtkXZsJLncBxzcgWh0_UHrl541%3A1732555871814' -L -o '1000G_5P.tar.gz'
  3. Download the 1000 Genomes Variants (MAF > 1%): 
    curl --header 'Host: drive.usercontent.google.com' --header 'User-Agent: Mozilla/5.0 (X11; Linux x86_64) AppleWebKit/537.36 (KHTML, like Gecko) Chrome/129.0.0.0 Safari/537.36' --header 'Accept: text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7' --header 'Accept-Language: en-US,en;q=0.9' --header 'Cookie: HSID=AoF9m_6tVeb09qDxB; SSID=AD-DXipuaombsBh0h; APISID=q36TGuYIe-cEv-fE/AV2VZf2ieU1cq1Igl; SAPISID=xMDkAfz0wKEwv8TL/A0IzvH3245W_Ao0TJ; __Secure-1PAPISID=xMDkAfz0wKEwv8TL/A0IzvH3245W_Ao0TJ; __Secure-3PAPISID=xMDkAfz0wKEwv8TL/A0IzvH3245W_Ao0TJ; S=billing-ui-v3=a9O0G9E9aDMupi7g1hLo9JY8pXcOwjYg:billing-ui-v3-efe=a9O0G9E9aDMupi7g1hLo9JY8pXcOwjYg; __Secure-ENID=23.SE=FF3F14B6WvDGdNY5IVFcjj2qMFKbGWbbjhNqiqkLxFG2oHfHtt2tnXGCjAJnTCwVqcrWEEapt_NteVQfEW9i-qtpqxLaTLsFUk0JJh5qvD4b2UEOcGaSqyltxuGQkoHrttfymgP4TMrPCfTMNt2xAzDGhFWMQ7REnQx_SPlhgAz9eJ07dMOaz6lOzNS5qkrwlQYPIUXE3AHGzg_mPEBKVtSiswkg71k8r8nnQ8Kkhdr8QlPxKEDjkocnV-hzhxClKWvI8aszkoNVLnopDdl7d-FRVb2FB3y_zLdcuty_lovUluU2qnxK67ZqLs_haSiIwupaDyLlLFvOlNgHQgUa3jQIal3QG3JAGhMOUPdNFga49A; SID=g.a000pwh4bxY6L7SRGa2NgTvkbkHqowyFc-VmrsLTBb4Bn-glvwPWmUosf97LDrHCniV3rhU9jwACgYKATASARUSFQHGX2Mi1AX2gxbq-i-IgVZBvuXcixoVAUF8yKqjQkGjJlIxv0GRnpcmeuWR0076; __Secure-1PSID=g.a000pwh4bxY6L7SRGa2NgTvkbkHqowyFc-VmrsLTBb4Bn-glvwPWZW2LCQ1nPyRoEV8PrMbcUAACgYKAU4SARUSFQHGX2MiDyMcSgv-3DYYi74i6Duf4xoVAUF8yKp2kt2FakB5-fVOlflvj18v0076; __Secure-3PSID=g.a000pwh4bxY6L7SRGa2NgTvkbkHqowyFc-VmrsLTBb4Bn-glvwPW_Mr9JgT-NhNItkIbcdUF8wACgYKAdcSARUSFQHGX2MiiAFSVmBNls1NPOhNHjBLrxoVAUF8yKr_B6OKBO5LEiZlqI8FhMdS0076; OSID=g.a000pgh4b5JZdIOotyBDt4f48llvybqkk49ek_LxWzjMUSyoX4tybN3JFc2uTfjP5DXeFzS7AQACgYKAbUSARUSFQHGX2MiiUeSGldKclTsgKYQ8hrK8BoVAUF8yKpfq61K8N8xSZ8IiJ-Fqsji0076; __Secure-OSID=g.a000pgh4b5JZdIOotyBDt4f48llvybqkk49ek_LxWzjMUSyoX4tyK6Ij1mUddYQFg7JOy35pXAACgYKAe4SARUSFQHGX2Mine7zuzmciEmpjJ00r_eMpRoVAUF8yKowhBBZbgC77Arqx6wbfA870076; AEC=AZ6Zc-XlHyhyvDszKJ2zEd5oHwFuRMhi50rJ5j554OKU8f2gP8qs5Sy2zw; NID=519=YRAuI47MT-mQo1GMo8ySboib3Ggz35QGzn9I5GE9fCuRRDtAA60P8wEyp2T96V1H7EDPsq9CLXWrgr_uh9SujYeMolN6bjWX6mZDJhmmNQCNeoTZEj2_nqFXa3lKIAJtjT2zDLpkBy7fNA7Plckn9-n1_2TUJI8kwcgy2ZTvk5EFc2Mqnk4LxkzefChabQCkgdKtCr7QQeamGGKs5AdKOQOz0emHwJopegGUUJFbCMbMkjGuO52Svezn8Rj7gINZdsRzSxu75rGKK3O73lyOO2PEyvzu7Tsj3Zf9UOkzOqDwfXJ-Xyl-zO_ZSPQP3E9bOeWOZPn4L8l2JXGviLU1st-hsbLuvjnUF1luZXTKwBKN3JennoNQl0HBzZSJ5Ls5n0VNAemgMA; __Secure-1PSIDTS=sidts-CjIBQT4rX9aHHfFL0QD5RBy5a2HOFYfa88q3NGcsBZD6Y95-jmz5wSzppyslHwxry8VJxRAA; __Secure-3PSIDTS=sidts-CjIBQT4rX9aHHfFL0QD5RBy5a2HOFYfa88q3NGcsBZD6Y95-jmz5wSzppyslHwxry8VJxRAA; SIDCC=AKEyXzUiO_pLVAb23idvGPu7fHoi3Dwr0MlkRTq-3mfdJvUoJ5LnQZVsEpIqYOcDwzG_c6b58MNd; __Secure-1PSIDCC=AKEyXzXpb6cPwIVV-O6nZGS4DLJ6n2eSQ-tn7H2Tr4qzm-dPszPhrc5uMGs7gigI9ciHK1zu_sE; __Secure-3PSIDCC=AKEyXzWX3r7mum9LZCsP8e1L5-vcVusdBRGI1lbxGg5EO0_enN49Hw3LnG9RXt9SCqxno649eNY' --header 'Connection: keep-alive' 'https://drive.usercontent.google.com/download?id=18xgsyDymbjeSOv1QS2ULQFaru5NVjwGR&export=download&authuser=0&confirm=t&uuid=c9c72932-d3eb-469c-b7d7-5bc87e7ea9e3&at=AENtkXZB1O2wYgcHdAbK8cKi3EBZ%3A1732556118270' -L -o '1000G_1P.tar.gz'

Unzipping Large Files on the Command Line:

Reference panels can then be unzipped into where bridgePRS reference panels are stored using the following command: 

tar -zxvf "REF_PANEL.tar.gz" -C "PATH-TO-BRIDGE-PRS-PANELS"