BridgePRS is a Bayesian-ridge (Bridge) approach, which "bridges" the PRS between two populations of different ancestry, developed to tackle the "PRS Portability Problem". The PRS Portability Problem causes lower accuracy PRS in underrepresented populations due to the biased sampling in GWAS data collection.
Package Downloads
| Operating System | Link | Notes |
|---|---|---|
| Linux 64-bit | v1.0.2 | Updated 1-20-2024 |
| Mac 64-bit | v1.0.2 | Updated 1-20-2024 |
| Windows | NA | Not Available |
| 1000G Ref Panel | 1000G_ref.tar.gz | Optional (Unzip into data directory to use) |
Latest Updates
2023-09-15 (v0.1.7)
- We have added sample thousand genomes data.
- update log can be found here
Overview
- BridgePRS is a software package written in R (main) and Python (wrapper) that depends on Plink. For more information on installing dependencies, please refer to Requirements.
- To get bridgePRS running using toy data see our Quick Start Tutorial..
- Following the Quick Start, the full guide provides more realistic examples to help you get started with your own data.
Citation: Our Manuscript is published in Nature Genetics
Please cite our paper:
Hoggart C, Choi SW, García-González J, Souaiaia T, Preuss M, O'Reilly P. BridgePRS leverages shared genetic effects across ancestries to increase polygenic risk score portability. Nat Genet 56, 180–186 (2024). https://doi.org/10.1038/s41588-023-01583-9
Contact
For questions about the methodology, this website, or our manuscript please contact Dr Clive Hoggart, Dr Tade Souaiaia, or Dr Paul O'Reilly. For source code and coding issues please visit the bridgePRS github here.
Acknowledgements
We would like to thank Brian Fulton-Howard for his feedback and help with testing.