Interpreting Results
The easyrun command used in the previous step sequentially runs five different subprograms in output directory supplied on the command line (eg. out1 and out2):
prs-single (stage 1):
Run PRS using the target population only (AFR).build-model:
Estimate SNP weights & prior params from model pop (EUR).prs-port (stage 1.5):
Run target-PRS using the model snp weights.prs-prior (stage 2):
Run target-PRS using model prior distributions.analyze
Combine results to produce a weighted target PRS result.
And produces output in the following five subdirectories:
- prs-single_AFR/quantify/: Weights, predictions, and performance metrics.
- model_EUR/prior: Model weights and priors.
- prs-port_AFR/quantify/: Weights, predictions, and performance metrics.
- prs-prior_AFR/quantify/: Weights, predictions, and performance metrics.
- prs-combined_AFR/: Analysis that combined the previous four steps.
The directory structure created by this command is shown below: